生物制药系-丛方地简介

个人简介

丛方地，男，汉族，1968年生人，博士，教授。天津市企业科技特派员，天津市农业科技特派员。 

研究领域

生物催化 

讲授课程

生物化学、生化制药、生物制药专业导论，等 

科研项目

1. “粮油质量安全过程保障与追溯技术集成与示范”“课题5粮油原料品质劣变风险预警防控系统的研究与应用示范”， 中华人民共和国科技部国家重点研发计划专项项目，60万，第四参与人。 

2.马铃薯过氧化物酶的收集及其在调水中的应用研究，天津市水产生态及养殖重点实验室开放基金重点项目，3.1万元，主持。 

3.鱼用维C酯的酶促合成与抗病效果研究，天津市水产生态及养殖重点实验室开放基金重点项目，3万元，主持。 

4.基于超细粒子吸附的Bt蛋白构象与生物活性和持效期关系研究，国家自然科学基金项目，第二参与人。 

5.大蒜油与中草药提取物复方促生长饲料添加剂的研制与开发，天津市科技计划项目，主持。 

6.有益菌种混合发酵的开发与应用，天津市企业科技特派员项目，2万元，主持。 

7.生物合成中酶活性与立体选择性的研究，国家自然科学基金委员会（面上项目），28万元，第四参与人。 

8.基于航空航天显示期间用铁电液晶的制备，中国博士后第四十一批科研基金资助（一等），5万元，主持。 

科研成果

1.Chenghong Ma, Shulin Zhang,Fangdi Cong,Yanling Xu, Jingjing Zhang, Dajuan Zhang, Liwang Zhang, Yongpeng Su. Sustained oxygen release of hydrogen peroxideacrylic resin inclusion complex for aquaculture. J Polym Eng, 2022, doi.org/10.1515/polyeng-2022-0077.

2.Xinran Liu,Fangdi Cong,Mengyao Han, Liwang Zhang, Zhongli Wang, Lu Jiang, Bingqian Liu, Shulin Zhang, Wei Yang, Yongpeng Su, Tao Li, Yingchao Wang, Daying Liu. Copper Phthalocyanine Improving Nonaqueous Catalysis of Pseudomonas cepacia Lipase for Ester Synthesis. Applied Biochemistry and Biotechnology, 2022, 194: 6302–6318.

3.Ping Li, Wei Yang,Fangdi Cong,Ailin Zhang, Shulin Zhang, Yingchao Wang, Yongpeng Su, Daying Liu, Haixue Liu, Tao Li, A microchemical analysis of acid values in stored wheat. Cereal Chemistry. 2022, 99: 811–818.

4.Min Yuan,Fangdi Cong,Yali Zhai, Ping Li, Wei Yang, Shulin Zhang, Yongpeng Su, Tao Li, Yingchao Wang, Wei Luo, Daying Liu, Zhongqiu Cui. Rice straw enhancing catalysis of Pseudomonas fluorescens lipase for synthesis of citronellyl acetate. Bioprocess and Biosystems Engineering, 2022, 45: 453–464.

5.Cong, F.,Jiang, H., Du, X., Yang, W., & Zhang, S. Facile, mild-temperature synthesis of metal-free phthalocyanines. Synthesis. 2021,53(15): 2656-2664.

6.Yali Zhai,Fangdi Cong,∗Min Yuan, Shulin Zhang, Ping Li, Yingchao Wang, Wei Yang, Haixue Liu, Wei Luo, Yongpeng Su, Liming Zhao. Melia azedarach leaf powder stabilizing Pseudomonas fluorescens lipase to catalyze synthesis of geranyl acetate. Biocatalysis and Agricultural Biotechnology, 2021, 37: 102170.

7.陈璐;刘黎瑶;丛方地;我国粮食安全的挑战性问题分析及应对策略探,粮油与饲料科技, 2021,6: 1841-5.

8.任德忠，丛方地^*,王晓红，张蒙，王鑫鑫，张树林，罗巍. PCL生物反应器中催化合成乙酸正戊酯.天津农学院学报, 2020, 27(1): 65-69.

9.张蒙;丛方地;任德忠;王晓红;王鑫鑫;张树林;罗巍.静置的固定化荧光假单胞菌脂肪酶(PFL)生物反应器中催化合成乙酸香茅酯.生物加工过程, 2020, 18(05): 572-576. 

10.Xin Li,Fangdi Cong^*, Shulin Zhang*, Dajuan Zhang, Xinxin Wang. A Review on Recognition of Various Peroxidases. International Journal of Bioorganic Chemistry. 2019, 5(1): 10-14.

11.Wenwen Cao,Fangdi Cong^*, Jie Kang, Shulin Zhang, Xin Li, Xinxin Wang, Ping Li, Jinze Yu. A simple room temperature-static bioreactor for effective synthesis of hexyl acetate. Green Process Synth, 2020; 9: 48–55.

12.Ping Li,Fangdi Cong^*, Shulin Zhang, Wenli Zhou, Hualing Zhu, Yanling Xu, Jinze Yu. Quantification of total lipids based on the characteristic absorption of tetra-b-(2-octanyloxy)-substituted nickel phthalocyanine. Anal. Methods, 2019, 11: 5629-5637.

13.Xin Li, Shulin Zhang,Fangdi Cong^*, Tao Li, Dajuan Zhang, Xinxin Wang and Yuying Li, Potato catalase-promoted rapid release of oxygen from hydrogen peroxide used in aquaculture. International Journal of Fisheries and Aquatic Studies, 2019, 7(5): 136-143.

14.Ping Li,Fangdi Cong^*, Shulin Zhang,* Haixue Liu, Yanling Xu，Jing Cui，A novel way for the determination of the acid values of edible oils using a phthalocyanine derivative. Analytical Methods, 2018, 10(32):3984-3990.

15.Xiao Wang, Xiaohong Wang,Fangdi Cong,Yanling Xu, Jie Kang, Ying Zhang, Meijuan Zhou, Kezhi Xing,Guirong Zhang，Hong Pan，Synthesis of cinnamyl acetate catalysed by highly reusable cotton-immobilized Pseudomonas fluorescens lipase. Biocatalysis & Biotransformation, 2018，36（4）: 332-339.

16.周美娟，张莹，丛方地^*，张树林，刘黎瑶，罗巍.乙酸肉桂酯在固定化脂肪酶反应器中的合成.天津农学院学报, 2018, 25(1): 64-67, 80.

17.徐文婷，毕武丹，丛方地^*，李月影，张文静，于琬琪，张树林,杨薇，罗巍.固定化脂肪酶ANL非水催化合成L-抗坏血酸棕榈酸酯.生物加工过程. 2018, (4): 36-39.

18.吕欣，于婉琪，关欣，周雪清，毕武丹，张树林，丛方地^*. CMC调节脂肪酶催化合成L-抗坏血酸棕榈酸酯.中国食品添加剂, 2017, (2): 70-74.

19.康洁，王笑，张莹，周美娟，丛方地^*，邢克智^*.脱脂棉固定化脂肪酶的非水活性与稳定性.中国生物化学与分子生物学报, 2017, 33(4): 386-390.

20.丁俊竹，丛方地^*，詹美榕，康洁，周文礼，邢克智^*.固定化荧光假单胞菌脂肪酶催化合成乙酸癸酯.中国食品添加剂, 2017, (3): 122-126.

21.张莹，周美娟，丛方地^*，王晓红，张树林，刘海学，任健，杨薇.脱脂棉固定化脂肪酶PCL催化合成乙酸癸酯.中国食品添加剂, 2017, (12): 51-56.

22.毕武丹，徐文婷，丛方地^*，吕欣，张树林，刘黎瑶，杨薇.固定化脂肪酶Pseudomonas cepacialipase催化合成L-抗坏血酸棕榈酸酯.上海：2017第三届生物制药峰会, 2017, 1-6.

23.王彦玲，赵赛，丛方地^*，张树林. 3种益生菌的混合发酵探索.饲料研究. 2017, (2): 48-50.

24.Fang-Di Cong^*,Jie Kang, Wu-Dan Bi, Tao Li, Ping Li, Kinetic Resolution of(R,S)-1-chloro-3-(1-naphthyloxy)-2-Propanolin an Immobilized Lipase Bioreactor. Biochemistry and Molecular Biology, 2016, 1(3): 34-38.

25.詹美榕，丁俊竹，丛方地^*，邢克智，周文礼，张树林.调节黑曲霉脂肪酶催化合成己酸乙酯的探索.酿酒科技, 2016, (12): 28-30.

26.Fangdi Cong, Zhen Wei, Zhiqiang Huang, Fengyang Yu, Haixue Liu, Jing Cui, Helong Yu, Xinxin Chu, Xiguang Du, Kezhi Xing, Jianhong Lai. Characteristic absorption band split of symmetrically tetra-octyloxy metal phthalocyanines.Dyes and Pigments2015, 120: 1-7.

27.王岁迪，王双双，丛方地^*，胡兴超，邢克智，王媛媛，张莹.丙烯酸树脂调节假单胞菌脂肪酶(PCL)的催化作用.食品科技, 2015, 40(10): 211-215.

28.丛方地^*，王海风，张媛媛，于丰洋，朱华玲，张树林^*.大蒜油的预乳化及分散性研究.日用化学工业. 2015, 45(9): 495-499.

29.刘昱杉,胡兴超,丛方地,王岁迪,王彦玲,王双双，邢克智，关欣，吕欣，赵赛，张莹，王笑，周美娟.荧光假单胞菌脂肪酶(pfl)的固定化及催化合成乙酸肉桂酯.中国食品添加剂, 2015, 6: 140-144.

30.闫倩云,李玲玲,丛方地,刘海臣,周学永,邢克智等.固定化脂肪酶生物反应器催化合成乙酸正己酯.食品工业科技,2015,36(9): 171-174.

31.Fangdi Cong,Haifeng Wang, Jianxin Li, Lingling Li, Qianyun Yan, Xinxin Chu, Yanyan Meng, Kezhi Xing, Xiguang Du. Improved Synthesis and Chromophoric Properties of Tetra-β-(2-octanyloxy) substituted Nickel Phthalocyanine.Asian J Chem, 2014, 26(8): 2351-2356.

32.李玲玲,闫倩云,丛方地,周学永,刘海学,邢克智,任 健,王英超,李 涛.器壁固定化脂肪酶(Pseudomonas cepacia lipase)的非水活性与稳定性.中国生物化学与分子生物学报, 2014, 30(10): 1025-1030.

33.丛方地,王庆奎,周文礼,邢克智.水产养殖中多糖的非特异性免疫研究.饲料工业,2014,35(19): 65-69.

34.Fangdi Cong,Kezhi Xing, Renjun Gao, Shugui Cao and Guirong Zhang, Enhanced activity and enantioselectivity of a hyperthermophilic esterase from archaeon Aeropyrum pernix K1 by acetone treatment.Appl Biochem Biotech,2011, 65(3-4): 795-801.

35.Fangdi Cong, Zixiang Cui, Li Li, Junshan Gao, Xiguang Du, Kezhi Xing, Tetra-β-(2-(diethylamino) ethoxy) nickel phthalocyanine: synthesis and inclusion in MCM-41. J Incl Phenom Macro, 2011, 71(1-2): 225-230.

36.Fangdi Cong,Xiuyan Wang, Gui Gao, Xiguang Du, Zhen Wei, Fengyang Yu, Junbin Wang, Guojing Yu, Bin Chen, Kezhi Xing, Facile Synthesis of a Water-Soluble Cobalt Phthalocyanine Derivative.Asian J Chem,2011, 23(2): 645-648.

37.解金兰,丛方地.脂肪酶活性部位上的盖与界面活性.中国生物化学与分子生物学报, 2011, 27(6): 499-504.

38.Fandi Cong,Gui Gao, Jianxin Li, Guoqing Huang, Zhen Wei, Fengyang Yu, Xiguang Du, Kezhi Xing. Synthesis and aggregation study of optically active tetra-β-[(S)-2-octanyloxy]-substituted copper and nickel phthalocyanines.J Chem Sci,2010, 122(6): 813-818.

39.Fangdi Cong, Guojing Yu, Kezhi Xing, Bin Chen, Facile Synthesis of a Carboxyl-functionalized Zinc Phthalocyanine.Synth. React. Inorg. M,2010, 40(2): 109-111.

40.胡远书,胡福平,刘晨,丛方地,刘海学.有机相中测定酶psl活性研究.安徽农业科学, 2010, 25: 13620-13621.

41.Fangdi Cong, Dongliang Tian, Junshan Gao, Wenjuan Duan,Chunyu Ma, Xiguang Du, Synthesis, characterization and photostability of several soluble tetra(quinolin-8-yloxy)metallophthalocyanines.Inorganica Chimica Acta,2009, 362: 243-246.

42.Fangdi Cong,Jianxin Li, Chunyu Ma, Junshan Gao,Wenjuan Duan, Xiguang Du, Tuning J-type dimers of non-peripherally substituted zinc tetra-4-tert-butylpheno phthalocyanine.Spectrochimica Acta Part: A,2008, 71: 1397-1401.

43.Fangdi Cong,Wenjuan Duan, Jianxin Li, Junshan Gao, Xiguang Du. Synthesis and Characterization of Soluble Tetra(2-methoxyethoxy)metallophthalocyanines.J. Heterocycltc Chem, 2008, 45: 1755-1759.

44.Fangdi Cong,Bo Ning, Yiping Ji, Xiuyan Wang, Fubo Ke, Yunyu Liu, Xiujun Cui, Bin Chen. The facile synthesis and characterization of tetraimido-substituted zinc phthalocyanines. Dyes and Pigments, 2008, 77: 686-690.

45.Fang-Di Cong,Yuan-Hong Wang, Chun-Yun Ma, Hai-Feng Yu, Si-Ping Han, Jin Tao, Shu-Gui Cao. A way for resolution of (R, S)-2-octanol by combining dynamic kinetic resolution with double kinetic resolution. Enzyme and Microbial Technology, 2005, 36: 595–599.

46.Fang-Di Cong,Bo Ning, Hai-Feng Yu, Xiu-Jun Cui, Bin Chena, Shu-Gui Cao, Chun-Yu Ma. The control of phthalocyanine properties through nitro-group electronic effect. Spectrochimica Acta Part A, 2005, 62: 394–397.

47.Fang-Di Cong, Bo Ning, Xi-Guang Du, Chun-Yu Ma, Hai-Feng Yu, Bin Chen. Facile synthesis, characterization and property comparisons of tetraaminometallophthylocyanines with and without intramolecular hydrogen bonds. Dyes and Pigments, 2005,66: 149-154.

48.宁波,隋加平,王元鸿,崔秀君,邵长路等.两种四苯甲亚胺基酞菁锌(Ⅱ)的合成及其紫外可见光谱的研究.分子科学学报(中、英文）,2005, 21(2): 31-35. 

49.丛方地,宁波,杜锡光,陈冬菊,陈彬.四氨基取代金属酞菁的光谱分析.分子科学学报,2004, 20(1): 27-32.

50.丛方地,杜锡光,赵宝中,刘群,陈彬.两种四氨基铜酞菁异构体的合成及其分子中氨基的稳定性研究.分子科学学报(中、英文）, 2003, 19(1): 26-32.

51.宁波,丛方地,马春雨,陈冬菊,刘颖,陈彬.四邻苯二甲酰亚胺基金属酞菁的合成及其性质研究.分子科学学报,2003,19(4): 228-232.

52.丛方地,杜锡光,赵宝中,刘群,陈彬..两种四氨基锌酞菁异构体的简易合成及其表征.高等学校化学学报, 2002,23(12): 2221-2225.

53.Fangdi Cong^*, Ping Li, Liyao Liu, Tao Li. Investigation and Analysis on Feeling of Undergraduates Majoring in Biopharmaceutical After Thesis Defense. International Journal of Education, Culture and Society, 2018, 3(1): 5-9.

54.Fangdi Cong,Xiaohong Wang, Ping Li, Shulin Zhang. Transformation of scientific research into teaching-A case of enzymatic mechanism and kinetics. Asian Education Studies, 2018, 3(3): 44-49.

55.生物化学（第四版），ISBN 978-7-109-23782-7，普通高等教育农业部“十三五”规划教材，全国农林院校“十三五”规划教材，京津冀都市型现代农业特色规划教材，中国农业出版社，2018.7，主编。 

56.生化制药简明教程，ISBN: 9787109220546，(京津冀都市型现代农业特色规划教材；全国高等农林院校十三五规划教材)，中国农业出版社，2021.8，主编。 

57.生物化学（第三版），ISBN 978-7-109-14842-0,全国农林院校“十一五”规划教材，中国农业出版社，2010.8，副主编。 

58.生物化学习题集（第三版）. ISBN：978-7-109-18043-7，中国农业出版社, 2013.5,第二主编。 

59.三合一多功能预混合液体饲料及其制备方法, ZL201010255581.5,第一发明人。 

60.一种复合菌混合培养装置, ZL201020279489.8,第一发明人。 

61.矿物质和氨基酸液体复合预混合饲料, ZL201010253041.3,第一发明人。 

62.一种复合矿物质液体预混合饲料, ZL201010253127.6,第一发明人。 

63.提高产蛋量的中草药饲料添加剂, ZL201010253128.0,第四发明人。 

64.一种连续可调兽用灌药器, ZL201120055340.6,第一发明人。 

65.一种速溶小檗碱制剂及其制备方法和应用, ZL201410669153.5,第二发明人。 

66.一种养殖用虾棚, ZL201821856358.4,第四发明人。 

67.一种标粗虾养殖阶段用双层养殖棚, ZL201821758972.7,第三发明人。 

68.一种带有喷淋系统的水产养殖用棚, ZL201821771749.6,第四发明人。 

69.一种定量总脂含量的分光光度法及应用, ZL201910274382.x,第一发明人。 

70.一种天然植物抗病毒组合物、该组合物发酵装置及方法, ZL202210497594.6,第二发明人。 

获奖情况

1. 2023年，天津市科学技术进步奖（第5）。 

2. 2021年，天津市入住企业优秀科技特派员 

3. 2018年，《生物化学》（第4版）农业部“十三五”规划教材。 

4. 2018年，天津市教学成果一等奖 （第3）。 

5. 2018年，天津现代水产生态健康养殖创新团队成员。 

6. 2017年，天津市入住企业优秀科技特派员 

7. 2011年，中华农业科教基金会全国高等农业院校优秀教材奖。 

8. 2011年，指导本科生获天津市‘十一届’挑战杯作品竞赛二等奖。 

9. 2009年，校企合作纳米维生物相关研究国内领先。 

10. 2008年，校企合作多功能预混料研究国内领先。