李国帅 简介

个人简介

李国帅，男，1994年生人，博士，讲师。

研究领域

过渡金属催化合成反应、农药分子创制

讲授课程

生物资源综合利用、精细化学品化学、实验化学

科研项目

1. 多模态非共价作用调控氮杂芳烃的远端碳氢键官能化反应研究（2025天津农学院青年科技人才发展基金项目，主持）

2. 基于非共价氢键作用的不对称碳氢键官能化反应研究（国家自然科学基金面上项目，参与）

3. 全新结构的HPPD抑制剂苯并噻唑酮类先导结构的优化及其在稻田杂草防控的应用（国家自然科学基金面上项目，参与）

科研成果

1. Guoshuai Li, Yifei Yan, Jinghong Tang, et al. Regiodivergent Remote C–H Functionalization by Tuning Template Geometry. Organic Letters, 2024, 26, 4733−4737.

2. Guoshuai Li, Yifei Yan, Pengfei Zhang, et al. Palladium-Catalyzed meta-Selective C−H Functionalization by Noncovalent H‑Bonding Interaction. ACS catalysis, 2021, 11, 10460−10466.

3. Guoshuai Li, Junfeng Zhang, Zhifang Liu, et al. Development of a Series of 4-Hydroxycoumarin Platinum(IV) Hybrids as Antitumor Agents: Synthesis, Biological Evaluation and Action Mechanism Investigation. Journal of Inorganic Biochemistry, 2019, 194, 34−43.

4. Qingpeng Wang*, Guoshuai Li, Zhifang Liu, et al. Naphthalimide Platinum(IV) Compounds as Antitumor Agents with Dual DNA Damage Mechanism to Overcome Cisplatin Resistance. European Journal of Inorganic Chemistry, 2018, 40, 4442−4451.

5. Jinghong Tang, Jun Huang, Guoshuai Li, et al. Palladium-Catalyzed para-Selective C–H Olefination and Acetoxylation of Benzylamines Enabled by an Unmasked Benzoyl Template. Organic Letters, 2024, 26, 29, 6109–6113.

6. Qingpeng Wang*, Yan Chen, Guoshuai Li, et al. A potent aminonaphthalimide platinum(IV) complex with effective antitumor activities in vitro and in vivo displaying dual DNA damage effects on tumor cells. Bioorganic & Medicinal Chemistry Letters, 2019, 29(20):126670.

7. Pengfei Zhang, Zhiwei Jiang, Zhoulong Fan, Guoshuai Li, et al. Macrocyclization via remote meta-selective C–H olefination using a practical indolyl template. Chemical Science, 2023, 14, 8279.

8. Qingxue Ma, Fengdong Wang, Pengfei Zhang, Guoshuai Li et al. Pd(0)/Xantphos-Catalyzed Benzylic C(sp³)–O Arylation of Benzyl Heteroaryl Ethers: Reduction of Pd(II) to Pd(0) by Xantphos. The Journal of Organic Chemistry, 2024, 89, 18, 13703–13708.